9-cis retinoic acid modulates the type I allergic immune response
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منابع مشابه
3-cis retinoic acid)-i nduced hyperlipidemia
A significant rise in plasma triacylglycerols from the control level of 0.89 mmovl to 1.88 mmom (P < 0.001) was observed in male Sprague-Dawley rats treated for 11 days with isomtinoin (oral dosing; 10 mg/day). This rise was due to an increased level of plasma very low density lipoproteins (VLDL). When VLDL from untreated rats were labeled with ‘251-labeled tyramine-cellobiose and injected intr...
متن کاملPharmacokinetics of 9-cis-retinoic acid in the rhesus monkey.
9-cis-Retinoic acid is a naturally occurring biologically active retinoid capable of binding and transactivating both the retinoic acid receptors and the retinoid X receptors. A study was performed to characterize the pharmacokinetics 9-cis-retinoic acid following i.v. bolus administration in the nonhuman primate. Groups of three animals received i.v. bolus doses of 9-cis-retinoic acid of eithe...
متن کامل9-cis retinoic acid signaling: changing partners causes some excitement.
Reports on the role of retinoids in cell metabolism can be traced back almost a century, when the then-unknown vitamin A present in dietary lipids was found to be essential for normal growth {McCollum and Davis 1913; Osborne and Mendel 1913}. Since then, the profound effect of retinoic acid IRA}, a derivative of vitamin A, on development and differentiation has been documented in numerous publi...
متن کاملIsomerization of all-trans-retinoic acid to 9-cis-retinoic acid.
The discovery of the biological activity of 9-cis-retinoic acid raises questions as to its mode of biosynthesis. A simple mechanism involves the direct isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. It is shown here that bovine liver membranes, but not supernatant fractions, can isomerize all-trans-retinoic acid into 9-cis-retinoic acid and 13-cis-retinoic acid. The concentrat...
متن کامل9,13-Dicis-retinoic acid as an isomerization product of 9-cis-retinoic acid.
With great interest we have read the article by Marchetti et al. on oxidation and isomerization of retinoic acid (RA) isomers in vitro, which was published in this journal recently (1). However, there are misleading statements in that publication, which require clarification. For instance, more than the indicated “few studies” on the metabolism of 9-cis-RA exist. Among the literature not referr...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2018
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.03.046